Long-Standing Persistant Atrial Fibrillation-Pulmonary Vein Isolation With or Without Ablation

Ablation at St. Georg Hospital for Long-Standing Persistent Atrial Fibrillation - Pulmonary Vein Isolation With or Without Ablation of Complex Fragmented Atrial Potentials

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00820625

Acronym

Alster-Lost

Enrollment

124

Registered

2009-01-12

Start date

2008-05-31

Completion date

2017-02-28

Last updated

2017-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation, Tachycardia

Brief summary

The chronic success rate, defined as freedom from any atrial tachyarrhythmias will increase from 35% to 60% by ablation of complex fragmented atrial electrograms potentials in addition to pulmonary vein isolation (PVI) as compared to PVI alone in patients with long-standing persistent AF.

Interventions

PROCEDUREpulmonary vein isolation

common pulmonary vein isolation procedure

PROCEDUREpulmonary vein isolation with additional ablation of fragmented potentials

common pulmonary vein isolation with additional but also common ablation of fragmented potentials

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* long standing persistent atrial fibrillation \> 6 months and \< 5 years

Exclusion criteria

* renal failure * left atrial size \>55 mm

Design outcomes

Primary

Measure	Time frame
data collection in view of acute and chronic success rate	12 months

Secondary

Measure	Time frame
data collection of complications in both groups and also procedure parameters	12 months

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 26, 2026