Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis

Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00819442

Acronym

DESMIN

Enrollment

Registered

2009-01-09

Start date

2009-01-31

Completion date

2011-06-30

Last updated

2009-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dilated Cardiomyopathy

Keywords

heart failure, desmin, ubiquitin

Brief summary

The purpose of this study is evaluation of expression of desmin in cardiomyocytes of patients with idiopathic dilated cardiomyopathy. Analysis of relationship between desmin expression and activities of mitochondrium and expression of ubiquitin.

Interventions

PROCEDUREcardiobiopsy

5 samples will be taken from right ventricle by Cordis bioptome

Study design

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* idiopatic dilated cardiomyopathy, NYHA I, II, III, IV * dilated left ventricle * ejection fraction below 45%

Exclusion criteria

* diabetes mellitus * kidney failure (GFR \< 30, creatinine below 2,5 mg/dl

Design outcomes

Primary

Measure	Time frame
all cause mortality	one year

Secondary

Measure	Time frame
qualitative differences in desmin expression in cardiomyocytes of patient with heart failure	one year

Countries

Poland

Contacts

Primary ContactAgnieszka Pawlak, PhD

a.pawlak1@wp.pl+48502133158

Backup ContactRobert J Gil, Professor

kardiologia.inwazyjna@cskmswia.pl+4822 5081100

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026