Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression

Associations Between Depression and Cardiovascular Disease in Patients With Late Onset, Single Episode Major Depressive Disorder

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00818506

Enrollment

Registered

2009-01-07

Start date

2009-03-31

Completion date

2012-06-30

Last updated

2012-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Disease, Coronary Artery Disease, Depression, Major Depressive Disorder

Keywords

Depression, Major depressive disorder, Coronary artery disease, White Matter Hyperintensities, White Matter Lesions, Coronary artery calcification

Brief summary

Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD. Among other mechanisms atherosclerosis is believed to play a central role regarding these notable associations between depression and CAD. Moreover, patients with late onset major depression have an increased number of small lesions found in the white matter of the brain, the so-called white matter lesions. The main goal of this project is to examine if CAD is associated with depression and/or white matter lesions. CAD is evaluated using coronary CT angiography. Depression is evaluated using a semi-structured diagnostic interview. White matter lesions are quantified using cerebral magnetic resonance.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

50 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Submitted to psychiatric hospital, district psychiatry or private psychiatrist because of major depressive disorder. * Meets the criteria for Major Depressive Disorder, Single Episode as defined in the Diagnostic and Statistical Manual, fourth edition (DSM-IV) and the International Classification of Diseases (ICD-10). * Age 50-70 years. * Written informed consent. * Caucasian.

Exclusion criteria

* Known, or anamnestic/objective signs of, organic brain disease. * Organic, including symptomatic, mental disorders as (ICD-10: F00-F09). * Dependence syndrome within the last 5 years (ICD-10: F1x.2) or current harmful use (ICD-10: F1x.1) of alcohol or other psychoactive substances. * Schizophrenia, schizotypal and delusional disorders (ICD-10: F20-F29). * Subject to force of law according to the danish law on psychiatry. * Present risk of suicide. * Previous cranial trauma resulting in unconsciousness for more than 2 minutes. * Medical history of renal failure. * Other conditions which contraindicate specific procedures in the project. * Other conditions deemed to prevent the subject from completing the examination program. * Does not want to participate.

Countries

Denmark

Outcome results