Chronic Kidney Disease, Sleep Loss
Conditions
Keywords
CKD, Kidney Disease, poor sleep, CKD progression
Brief summary
To test if usual at home night time sleep duration as measured with activity monitors and questionnaires will predict changes in kidney function as measured by kidney filtration rate and of cardiovascular function as measured by C-reactive protein in the blood. The study will explore the role of decreased sleep time or decreased sleep quality as a non-traditional risk factor for the progression of CKD and for the development of cardiovascular disease in CKD.
Interventions
None listed
Sponsors
University of Illinois at Chicago
Case Western Reserve University
University of Chicago
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to 74 Years
Healthy volunteers
Yes
Inclusion criteria
* Mild to Moderate CKD * Healthy controls age and gender matched to CKD subjects * Regular bedtimes of at least 6h/night, sedentary lifestyle
Exclusion criteria
* Diabetes * Current or previous dialysis for more than 1 month * Uncontrolled hypertension * Heart failure * Liver disease * HIV * Hemoglobin \< 10.5 g/dl * Treatment with EProcrit, Epogen, or Aranesp * Bone or organ transplant, * Use of immunosuppressive drugs within past 6 months * Current oral contraceptive use * Current pregnancy * Chemotherapy for malignancy within past 2 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CKD progression as measured by changes in GFR and cardiovascular risk as measured by CRP over a 5 year period | 5 years |
Secondary
| Measure | Time frame |
|---|---|
| insulin resistance | 5 years |
Countries
United States
Outcome results
None listed