Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00817440

Acronym

FEIGH

Enrollment

Registered

2009-01-06

Start date

2008-12-31

Completion date

Unknown

Last updated

2011-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

growth hormone insulin signaltransduction signalpathways, growth hormone and insulin signalpathways

Brief summary

Hypothesis: under fasting there will primarily be an activation of growth hormone(GH) signalpathways and a inhibition of insulin signalpathways, and the opposite will happen under physical activity. Primarily we will investigate markers for GH and insulin signaltransduction in muscle- and fat-biopsies after fasting for 72 hours and after 1 hour of ergometer-cycling at 65% Vo2max. In addition to this we will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Interventions

OTHERExercise

1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.

OTHERFasting

3 days of fasting and then the same as arm 1

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy men * Body mass index (BMI) 20-26 * age 18-45 years

Exclusion criteria

* any kind of disease * any use of medicine

Design outcomes

Primary

Measure	Time frame
Growth hormone and insulin signal pathways	30 min

Secondary

Measure	Time frame
aminoacid and glucose turnover	4 hours

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026