Sleep Disturbances as a Risk Factor in Chronic Kidney Disease

Sleep Disturbance as a Non-Traditional Risk Factor in CKD

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00817427

Acronym

CRIC

Enrollment

Registered

2009-01-06

Start date

2008-10-31

Completion date

2011-07-31

Last updated

2013-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease

Keywords

Chronic Kidney Disease, Poor sleep, CKD, Kidney Failure

Brief summary

This study is designed to determine if either short night time sleep or poor night time sleep could be a risk factor for increasing the rate at which kidney function deteriorates in persons with mild to moderate kidney disease.

Interventions

OTHERControls Short sleep

Healthy control subject's bedtime will be decreased by 2 hours/night with acoustic sleep disruption

OTHERCKD- sleep extension

Sleep will be increased by 2 hours each night for 3 nights

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to 74 Years

Healthy volunteers

Yes

Inclusion criteria

* Mild to Moderate CKD * Healthy controls age and gender matched to CKD subjects * Regular bedtimes of at least 6h/night, sedentary lifestyle

Exclusion criteria

* Diabetes * Current or previous dialysis for more than 1 month * Uncontrolled hypertension * Heart failure * Liver disease * HIV * Hemoglobin \< 10.5 g/dl * Treatment with EProcrit, Epogen, or Aranesp * Bone or organ transplant, * Use of immunosuppressive drugs within past 6 months * Current oral contraceptive use * Current pregnancy * Chemotherapy for malignancy within past 2 years

Design outcomes

Primary

Measure	Time frame
Comparison of chronobiological profiles of renin/aldosterone, sympatho-vagal balance and CV function in CKD subjects to controls at baseline and after extended sleep in CKD subjects and after decreased time and quality of sleep in control subjects.	Immediately after intervention.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026