Awake Fiberoptic Nasal Intubation
Conditions
Keywords
Dexmedetomidine, Fiberoptic nasal intubation, satisfaction
Brief summary
The objective of this study is to evaluate the feasibility of dexmedetomidine infusion for oral cancer patients undergoing awake fiberoptic nasal intubation. We hypothesized that a loading dose of intravenous dexmedetomidine before awake fiberoptic nasal intubation for oral cancer patients undergoing general anesthesia will provide adequate sedation and analgesia without respiratory depression and upper airway obstruction.
Detailed description
Case number: 60, ASA I-III oral cancer patients with limited mouth opening Patients will be randomly allocated into three groups, Dex group received dexmedetomidine (1.0 mcg/kg) infusion, Control group received saline, and Propofol group received 1% Propofol administrated usng effect-site TCI. Main outcome was evaluated by grading scores presenting conditions for nasal intubation, post-intubation and satisfaction. Other analysed parameters included airway obstruction, hemodynamic changes, treatment for hemodynamics response, consumption time for intubation, amnesia level, and postoperative adverse events. All outcome measurements were classified by scoring systems.
Interventions
DRUGdexmedetomidine
dexmedetomidine 1.0 mcg/kg infusion for 10minutes
DRUGNormal Saline 0.9%
0.9% Normal Saline 0.25ml/kg infusion for 10minues
DRUGpropofol 1%
Propofol: The initial target = 3 μg/ml. The TCI is adjusted by 0.5μg/ml according to patient comfort during the procedure. The Orchestra® Base Primea(Fresenius, Brezins, France) offers a Target Controlled Infusion (TCI) target controlled infusion.
Sponsors
Kaohsiung Medical University Chung-Ho Memorial Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Head and neck cancer patients with limited mouth opening * Undergoing awake fiberoptic nasal intubation for elective surgery
Exclusion criteria
* a history of severe bradycardia * any type of A-V block in EKG * heart failure * liver cirrhosis * thrombocytopenia * coagulopathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| grading scores presenting conditions for nasal intubation | before and after intubation |
Countries
Taiwan
Contacts
Primary ContactKoung-Shing Chu, Master
Backup ContactCheng-Jing Tsai
Outcome results
None listed