General Anesthesia
Conditions
Keywords
Inhalant anesthetic, Vasodilation, General anesthesia, Ultrasonography
Brief summary
Previous studies on animals suggest that inhalational anesthetics can reduce vascular tension in vitro resulting in vasodilation and decrease in blood pressure. This role for inhalational anesthetics has essential clinical implications such as the condition of sepsis or septic shock or other shock-associated states during which the blood vessel constricts strongly and leads to circulation dysfunction. The vasodilation property of these anesthetics including halothane, isoflurane, sevoflurane, desflurane and enflurane enables them to be better options than other general anesthetics in many clinical conditions needing the vasculature to be dilated. The investigators hypothesized that these inhalational anesthetics can evoke vasodilation measured with ultrasonography during general anesthesia in vivo as the in vitro studies displayed.
Interventions
DRUGHalothane
Induction: 2-4% halothane pluses 3-5 L/min oxygen Maintenance: different doses from 0.5% to 3% with 1-2 L/min oxygen
DRUGIsoflurane
Induction: 2-5% isoflurane pluses 3-5 L/min oxygen Maintenance: different doses from 1% to 4% with 1-2 L/min oxygen
DRUGSevoflurane
Induction: 3-8% sevoflurane pluses 3-5 L/min oxygen Maintenance: different doses from 1% to 4% with 1-2 L/min oxygen
DRUGDesflurane
Induction: 2-8% desflurane pluses 3-5 L/min oxygen Maintenance: different doses from 1% to 4% with 1-2 L/min oxygen
DRUGEnflurane
Induction: 2-5% enflurane pluses 3-5 L/min oxygen Maintenance: different doses from 1% to 4% with 1-2 L/min oxygen
Sponsors
Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Must be undergoing general anesthesia * Age between 19-45 years
Exclusion criteria
* With hypertension * Existing organic dysfunction * Allergic to inhalant anesthetics * Alcohol addictive or narcotic dependent patients * A history of the use of centrally-acting drugs of any sort, chronic pain and psychiatric diseases records
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ultrasonography of blood vessels including radial artery, brachial artery, femoral artery, popliteal artery | Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia |
Secondary
| Measure | Time frame |
|---|---|
| Blood flow volume during anesthesia of the vasculature | Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia |
| Blood pressure including systolic, diastolic and mean artery blood pressures | Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia |
| The time interval of between the initiation of the inhalational anesthetics delivered to the beginning of decreasing of blood pressure | From the beginning of anesthesia (0 min) till the first time of blood pressure decreased, this measure would be varied according to different individuals |
| The total dose of phenylephrine required to maintain baseline arterial blood pressure | From the beginning of anesthesia (0 min) to 20 min after anesthesia begun |
| Regression and correlation analyses between different doses of the anesthetics and the extent of vasodilation | Forty eight hours after operation |
Countries
China
Outcome results
None listed