Endotracheal Intubation
Conditions
Keywords
Remifentanil, Endotracheal intubation, Premedication, Sedation, Endotracheal Intubation in Neonates
Brief summary
The investigators hypothesize that the use of a combination of Atropine and Remifentanil will safely facilitate non emergent intubation procedure as effectively as the protocol of Atropine, Fentanyl, and Succinylcholine.
Interventions
DRUGAtropine/Remifentanil
Atropine 20mcg/kg Remifentanil 3mcg/kg
DRUGFentanyl/Atropine/Succinylcholine
Atropine 20mcg/kg Fentanyl 2mcg/kg Succinylcholine 2mg/kg
Sponsors
McMaster University
King Saud University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Hemodynamically stable neonates of any gestational age admitted to the Neonatal Intensive Care Unit at McMaster Children's Hospital requiring an elective endotracheal intubation was anticipated.
Exclusion criteria
* Urgent intubations * Cyanotic congenital heart lesions * Anticipated difficult airway * Concurrent or recently administered (within 3 hours of the procedure) intravenous opioid infusions * Pre-existing hyperkalemia * Family history of malignant hyperthermia * Prior enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to Successful intubation | 15 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Oxygen saturation | During the procedure up to 15 minutes |
| Heart Rate | During the procedure up to 15 minutes |
| Time to return of spontaneous respirations | 15 minutes |
| Intubation Condition | 15 minutes post procedure |
| Evidence of Trauma | 15 minutes post procedure |
| Blood Pressure | During the procedure up to 15 minutes |
Countries
Canada
Outcome results
None listed