Cesarean Delivery
Conditions
Keywords
Temperature, Spinal anesthesia, Cesarean section, Cephalad sensory blockade, Regional anesthesia
Brief summary
Several factors influence the extension of anesthetic mixture during spinal anesthesia including anesthetic gravity, body position, drug volume, and drug-delivering velocity. However, the effect of temperature of anesthetic mixture on the cephalad sensory blockade is hitherto unknown. The investigators hypothesized that different temperatures of the anesthetic mixture had different velocity of extension after spinal anesthesia. In addition, previous studies suggest that parturients have relative higher sensitivity to temperature. Herein the investigators proposed that the temperature of anesthetic mixture had more extensive effect on the cephalad sensory blockade with spinal anesthesia for cesarean delivery.
Interventions
DRUGbupivacaine/fentanyl/morphine
Hyperbaric bupivacaine 12 mg, fentanyl 10 microg and morphine 200 microg
Sponsors
Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
19 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
1. Nulliparous women 2. \> 18 years and \< 45 years
Exclusion criteria
1. Allergy to opioids, a history of the use of centrally-acting drugs of any sort, chronic pain and psychiatric diseases records 2. Participants younger than 18 years or older than 45 years 3. Those who were not willing to or could not finish the whole study at any time 4. Alcohol addictive or narcotic dependent patients 5. Subjects with a nonvertex presentation 6. Diagnosed diabetes mellitus and pregnancy-induced hypertension 7. Twin gestation and breech presentation 8. Pregnant fever
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximum cephalad sensory blockade to pinprick, cold and touch | From the delivery of anesthetic mixture to 15 min immediate after spinal anesthesia |
Secondary
| Measure | Time frame |
|---|---|
| Velocity of the sensory blockade at identical body position | From the delivery of anesthetic mixture to 15 min immediate after spinal anesthesia |
| The total dose of phenylephrine required to maintain baseline arterial blood pressure | From the delivery of anesthetic mixture to 25 min after spinal anesthesia |
| Time interval of the occurrence of the hypotension | From the delivery of the anesthetic mixture to 25 min after spinal anesthesia |
Countries
China
Outcome results
None listed