Acne Vulgaris
Conditions
Keywords
acne vulgaris, acne, dermatalogy
Brief summary
The goal of this study is to compare how efficient two different types of PDTs are when used in combination with topical 5-ALA. The two types of PDT lights are Blu-U light and Candela V-beam Pulse Dye Laser.
Interventions
DRUG5-ALA with Blu-U Light
20% 5-ALA Levulan Kerastick will be crushed and prepared for application after shaking for at least 3 minutes. Topical 5-ALA will be applied liberally on skin with extra pressure on lesions.Skin will be exposed to DUSA Blu-U light (417nm).
DRUG5-ALA with Candela V-beam Pulse Dye Laser
20% 5-ALA Levulan Kerastick will be crushed and prepared for application after shaking for at least 3 minutes. Topical 5-ALA will be applied liberally on skin with extra pressure on lesions.Skin will be exposed to Candela V-beam Pulsed Dye Laser (595 nm).
Sponsors
University of Chicago
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* 18-79 years of age * Patients who failed the topical and oral antibiotics after 6 month therapy. * Patients who failed the topical retinoids after 6 month therapy. * Patients that are not good candidate to start oral isotretinoin (Accutane) due to contraindications.
Exclusion criteria
* Patients who have had Isotretinoin therapy less that 1 year prior to this ALA-PDT procedure. * Patients who have an adverse reaction to light exposure (for example photo- exacerbated seizures). * Patients with a history of porphyria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acne complete /incomplete therapy and reoccurence | 18 months |
Secondary
| Measure | Time frame |
|---|---|
| Early skin responses 2 weeks post therapy (erythema, scaling, post inflammatory skin changes, fine wrinkling of skin, mottled pigmentation) | 2-18 months |
Countries
United States
Outcome results
None listed