Effect of β-alanine Supplementation on Muscle Carnosine

Effect of Two 8-week β-alanine Supplementation Protocols on Muscle Carnosine

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00813553

Acronym

LitmusMagnet

Enrollment

Registered

2008-12-23

Start date

2008-12-31

Completion date

2009-10-31

Last updated

2012-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

physical fitness, exercise, amino acid

Brief summary

Carnosine is a natural acid buffering substance of muscle. The primary objective of this study is to test whether a nutritional supplement of beta-alanine enhances carnosine content in muscle.

Detailed description

Volunteers will be randomized to receiving 3 nutritional supplements. Two supplements contain beta-alanine at different doses, the third supplement is a placebo.

Interventions

DIETARY_SUPPLEMENTplacebo

daily

DIETARY_SUPPLEMENTbeta-alanine

daily

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Stable health as evaluated by medical evaluation * Body mass index higher than 18 kg/m2 * Body mass index lower than 25 kg/m2, unless body fat is less than 20%

Exclusion criteria

* intolerance to β-alanine, * allergy to soy, fish and crustacean * participation in another intervention study * consumer of dietary supplement susceptible to contain beta-alanine * determined to have very high baseline muscle carnosine concentration

Design outcomes

Primary

Measure	Time frame
muscle carnosine concentration	0 to 8 weeks

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026