Ambulatory Anesthesia and Light Therapy

A Role for Light Therapy at Immediate Recovery From Short Duration Ambulatory Anesthesia to Prevent Dysregulation of Circadian Rest-Activity Rhythm in Patients Submitted to Colonoscopy.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00813345

Acronym

LI-AMB

Enrollment

360

Registered

2008-12-23

Start date

2009-01-31

Completion date

2010-06-30

Last updated

2009-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Colonoscopy

Keywords

anesthesia propofol ambulatory rhythm

Brief summary

We previously evidenced in both animal models and patients that a short duration ambulatory anesthesia impacts the circadian rest-activity biological rhythm, at least during the first 3 days. The light is the main, natural synchronisateur, of the biological cerebral clock, and is used as therapeutics in chronic disturbances of the circadian rest activity rhythm and of the sleep (Alzheimer disease for example). We would like to test for a simple and safe strategy to prevent such a long-lasting effect of anesthesia on biological clock:the increase of the light intensity at a still physiological level during the initial phase of recovery from anesthesia by using a particular artificial light of color spectrum similar to natural sun daylight.

Interventions

OTHERlight therapy (1500 lux)

light therapy (1500 lux) for 90 minutes

OTHERstandard light (100 LUX)

standard light (100 LUX) for 90 minutes

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

30 Years to 70 Years

Healthy volunteers

Inclusion criteria

* ASA I & II * ambulatory anesthesia for colonoscopy on Monday or Tuesday * social security

Exclusion criteria

* treatment for cancer * hypnotics, beta-bloquers * pregnancy * legal supervision * trans 5 meridian travel in the last two months

Design outcomes

Primary

Measure	Time frame
Modification of on parametric analysis of circadian rhythm of rest-activity post anesthesia as compared to reference period (within factor) ; between factor : light intensity group	Within the first 5 days after anesthesia

Secondary

Measure	Time frame
Influence of gene period 3 phenotype on the effect of anesthesia	Blood sample taken the day of the anesthesia

Countries

France

Contacts

Primary ContactLaure PAIN, MD

laurepain@aol.com+33(0)6 85 43 63 00

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026