Colorectal Cancer
Conditions
Keywords
average-risk subjects for
Brief summary
Adherence rate to screening colonoscopy (TC) in the average-risk general population is still unclear. Aim of this study was to compare the uptake of TC screening with that of fecal occult blood (FOBT) in the general population of different Italian areas.
Detailed description
A nationwide, population-based, multicenter, randomized trial comparing attendance to TC with that to FOBT was performed. Sixty-four general practitioners (GPs), overall including in their lists 9,889 average-risk subjects aged 55-64 years, were randomized between TC and FOBT screening programs. Eligible subjects were mailed a personal invitation letter co-signed by their GP and the coordinator of the area-reference GI centre. Attendance rate and detection rate for advanced neoplasia (colorectal cancer, adenoma \>10 mm or with villous histology or high-grade dysplasia) for each arm of the study were assessed.
Interventions
PROCEDUREcolonoscopy
colonoscopy screening
PROCEDUREfaecal test
faecal occult blood test for screening
Sponsors
Istituto Superiore di Sanità
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
55 Years to 64 Years
Healthy volunteers
No
Inclusion criteria
* asymptomatic 55-64 years subjects
Exclusion criteria
* already studied for colorectal cancer, severe comorbidities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Participation to colorectal cancer screening | — |
Countries
Italy
Outcome results
None listed