Weight Loss
Conditions
Brief summary
The purpose of this study is to identify how adult men respond to a weight loss diet that includes pork and eggs and increasing the number of meals consumed throughout the day. This is a 13-week study (12-weeks of weight loss and 1-week of baseline measurement).
Interventions
OTHEREnergy Restriction
Energy restricted diet of 750 kcal less than subjects requirement with a high protein diet.
Sponsors
Purdue University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
21 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age range: 21 years and older * Body mass index between 25.0-39.9 kg/m2 * Weight stable (\< 4.5 kg (\ 10 lbs) weight gain or loss within last 6 months) * Body fat \>25% (assessed by skinfold and plethysmography (if needed)) * Non-smoking (within the last 6 months) * Constant habitual activity patterns (within last 3 months) * Clinically normal blood profiles (specifically, normal liver and kidney function; fasting blood glucose \<110 mg/dl) * Not taking medications known to influence appetite or metabolism * Non-diabetic
Exclusion criteria
* Age: \<21 years * Body mass index: outside of the 25.0-39.9 kg/m2 range * Gained or lost \> 4.5 kg (10 lbs) within the last 6 months * Body fat \<25% as assessed by plethysmography * Smoker (currently or within the last 6 months) * Intermittently been involved in a diet and/or exercise program within the last 3 months * Clinically abnormal blood profiles as identified by our study physician, Arthur Rosen, MD * Taking medications (currently or within the last 3 months) known to influence appetite or metabolism * Clinically diagnosed as diabetic * Allergies to eggs * Lactose intolerance * Clinically diagnosed with diverticulosis * Clinically diagnosed with diverticulitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary aim is to examine the effects of increased protein intake on appetite, selected appetite hormones (insulin, leptin, ghrelin), whole body energy expenditure, and body composition (fat mass and fat-free mass) changes. | 12 week |
Secondary
| Measure | Time frame |
|---|---|
| The secondary aim of this study is to evaluate the effects of meal frequency on appetite by asking the men to frequently rate their appetite on days that they purposefully eat 3 vs. 6 times/day. | 12 week |
Countries
United States
Outcome results
None listed