The Effect of Gastric Bypass Surgery on the Glucose Metabolism Seen in Patients With Type 2 Diabetes

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00810823

Enrollment

Registered

2008-12-18

Start date

2009-01-31

Completion date

2011-04-30

Last updated

2011-07-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes

Keywords

Diabetes, gastric bypass, type 2 diabetes and gastric bypass

Brief summary

Gastric bypass surgery has in many studies shown total remission of type 2 diabetes as early as 1 - 2 days after surgery and this is before any real weight loss has occurred. This suggest that the remission of the diabetes is due to the direct effect of the operation more that the secondary effect of the weight loss. The reason for the major effect on the glucose metabolism after gastric bypass surgery is still unaccounted for. This PhD. project will try to unveil some of the mechanisms that could explain the effect of gastric bypass surgery on the glucose metabolism seen in patients with type 2 diabetes. The hypothesis of the study is that a factor X will course the remission of the diabetes. This factor X is related to the anatomic changes of the gastro intestinal tract, by eliminating the foods passage through the distal part of the ventricle and the duodenum, in combination with the Roux- en-Y sling. The PhD. project will consist of clinical trails on patients that will undergo gastric bypass surgery. The studies will take place before and within the 1. week after surgery. The investigators will measure different hormones and adipokines in fast and the postprandial state. To discover possible new proteins the investigators will run proteomic on some samples. All the results will be compared to the same parameter on patients undergoing gastric banding, where the anatomy of the intestine hasn't been changed.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* The inclusion criteria in Denmark for undergoing gastric bypass and see the above study and cohort description. * Well treated hypertension \< 145/85. HbA1C \<8,5 % and c-peptid\> 700pmol/l

Exclusion criteria

* In treatment with antidepressive, DPP-4 inhibitors and intreatment for thyroid problems. * Patients treated with insulin.

Design outcomes

Primary

Measure	Time frame
What is the factor X that cause the remission of type 2 diabetes after gastric bypass	about 3 years

Countries

Denmark

Outcome results