Hepatitis B, Chronic
Conditions
Keywords
Chronic hepatitis B, antiviral treatment, long term prognosis
Brief summary
Influence of antiviral treatment to the long term prognosis of patients with chronic HBV infection. The aim of antiviral treatment for HBV is to reduce the long term severe complications. In this study, the investigators divided patients with chronic HBV infection into two groups, which start early antiviral treatment and conventional antiviral treatment respectively. All the patients will be followed for ten years. From this study, the investigators want to find out the optimal time for patients with chronic HBV infection to start antiviral treatment.
Interventions
DRUGlamivudine
100mg, P.O.,QD, duration: until HBeAg seroconversion for more than 2years.
DRUGTelbivudine
600mg, P.O.,QD, duration: until HBeAg seroconversion for more than 2years.
DRUGEnticavir
0.5mg, P.O.,QD, duration: until HBeAg seroconversion for more than 2 years.
10mg, P.O.,QD, duration: until HBeAg seroconversion for more than 2years.
Sponsors
Sun Yat-sen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* HBsAg positive for more than 6 months. * HBeAg positive. * HBV DNA over 10E5 copies/ml.
Exclusion criteria
* Previous antiviral treatment for HBV. * Co infection of HIV, HCV, HEV, HAV, or HAV. * Evidence of hepatic carcinoma. * Evidence of autoimmune disease. * Evidence of thyroid disease. * History of mental sickness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence rate of hepatic carcinoma | 10 years after treatment |
| incidence rate of liver cirrhosis | 10 years after treatment |
| incidence rate of fulminant hepatitis | 10 years after treatment |
Countries
China
Contacts
Primary ContactGao zhiliang, M. D.
Backup ContactHuang zhanlian, M. D.
Outcome results
None listed