Blood Pressure, Heart Rate Variability
Conditions
Keywords
Air pollution, Heart rate, Heart rate variability, Blood pressure, Face mask
Brief summary
Exposure to air pollution is an important risk factor for cardiovascular morbidity and mortality, and is associated with increased blood pressure, reduced heart rate variability, endothelial dysfunction and myocardial ischaemia. The study objectives were to assess the potential cardiovascular benefits of reducing personal particulate air pollution exposure by wearing a facemask in healthy volunteers.
Interventions
DEVICEFace mask (Dust Respirator)
Subjects to wear a simple face mask for 24 hours prior to the study day and the 24 hours of the study day. They will be instructed to wear the mask as much as possible when indoors and at all times when outdoors.
OTHERNo Face mask
Subjects will not wear a face mask to reduce their personal exposure to air pollution
Sponsors
Peking Union Medical College
University of Edinburgh
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers
Exclusion criteria
* Current smokers * Significant occupational exposure to air pollution * Regular medication use (except oral contraceptive pill) * Intercurrent illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ambulatory blood pressure | During 24 hour study period |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate | During 24 hour study period |
| Heart rate variability | During 24 hour study period |
| Personal air pollution exposure | During 2 hour city centre walk |
Countries
China
Outcome results
None listed