Ampulla of Vater Cancer, Bile Duct Cancer, Pancreas Cancer
Conditions
Keywords
periampullar carcinoma, Pancreaticoduodenectomy, Enteral feeding, Total Parenteral Support
Brief summary
Pancreaticoduodenectomy is associated with a high incidence of postoperative complications. These postoperative complications could delay postoperative resumption of adequate oral intake. Clinical study on postoperative feeding after pancreaticoduodenectomy is very limited. Method of Nutritional support (Enteral feeding or total parenteral support)after pancreaticoduodenectomy is controversial. 1. To evaluate whether early enteral nutrition may be a suitable alternative to total parenteral nutrition 2. To evaluate whether enteral feeding improve nutritional status after pancreaticoduodenectomy
Detailed description
Pancreaticoduodenectomy is associated with a high incidence of postoperative complications. These postoperative complications could delay postoperative resumption of adequate oral intake. The use of TPN significantly increases postoperative complications, especially those associate with infections. However, method of Nutritional support (Enteral feeding or total parenteral support)after pancreaticoduodenectomy is controversial. 1. To evaluate whether early enteral nutrition may be decreased the postoperative complications 2. To evaluate whether enteral feeding improve nutritional status after pancreaticoduodenectomy 3. To determine the optimal method for postoperative nutritional support
Interventions
PROCEDUREEnteral Feeding and Total Parental Support
Enteral Feeding : 20ml/hr on POD1 * Velocity is progressively increased by 20ml/d until full nutritional goal (25Kcal/Kg)
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Periampullar carcinoma * Pancreaticoduonectomy * KARNOFSKY PERFORMANCE SCALE \> 70 * No history of Major operation
Exclusion criteria
* Creatinine level\>3mg/L * Ascitis/portal hypertension * New York Heart Association class\>3 * COPD * Preoperative Radiotheraly/chemotherapy * Unresectable primary cancer * Palliative surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the impact of early postoperative enteral feeding | Postoperative 21 days |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the nutritional status | Postoperative 6 months |
Countries
South Korea
Outcome results
None listed