Air Pollution, Exercise Performance, Pulmonary Artery Pressure, Pulmonary Hypertension
Conditions
Keywords
phosphodiesterase, sildenafil, pulmonary hypertension, exercise performance, air pollution
Brief summary
The purpose of this study is to examine if the ingestion of a standard dose of sildenafil enhances the athletic performance of competitive athletes when exercising in a high pollutant environment verses a low air pollutant environment.
Detailed description
This study will evaluate effects of sildenafil on exercise performance while breathing high levels of emission exhaust ultrafine and fine particulate matter. Exercise performance will be measured by work accumulation (total kJ) during a 6-min maximal effort cycle ergometer ride (CER) done immediately after 30 min cycling at 75% of 6 min mean watts determined from familiarization trial. Peak oxygen consumption, cardiac output, pulmonary artery pressure, diffusion capacity(DLco), and SaO2 will be determined for each trial. Blood and urine will be analyzed for sildenafil using LC/MS.
Interventions
DRUGsildenafil
sildenafil 50 mg ingested orally 1 hour prior to exercise testing
OTHERplacebo
matching placebo for sildenafil 50 mg to be ingested orally 1 hour prior to exercise testing.
Sponsors
Marywood University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* non-asthmatic * asthmatic * active participants in endurance sports.
Exclusion criteria
* history of high blood pressure * history of heart disease * pulmonary arterial hypertension * pulmonary emboli * diagnosis of moderate to severe asthma (FEV1 \<75% predicted) * pregnant or lactating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| That a decrease in exercise performance subsequent to emissions particle inhalation will be blunted by oral ingestion of 50 mg sildenafil prior to a 6-min maximal accumulation test (total kJ)on a cycle ergometer. | Cycle ergometer testing will be done one hour after administration of sildenafil or matching placebo. |
Secondary
| Measure | Time frame |
|---|---|
| That the decreased VO2 peak and decreased exercise performance from emissions inhalation will be the result of pulmonary hypertension causing decreased stroke volume. | Pulmonary artery pressure will be measured before and immediately post exercise. |
| That plasma and urine sildenafil and metabolites will be measurable by liquid chromatography mass spectrometry (LC/MS) 6 h post ingestion. | Blood and urine samples will be collected at 1, 3, 1nd 6 hours post exercise testing. |
Countries
United States
Outcome results
None listed