Dehydration
Conditions
Keywords
dehydration, fluid therapy, hyaluronoglucosaminidase, hyaluronidase, hypodermoclysis, clysis, subcutaneous hydration, subcutaneous rehydration, hyaluronan, rHuPH20
Brief summary
The purpose is to evaluate the ease of use and technical challenges encountered during subcutaneous infusion of Lactated Ringer's (LR) solution, preceded by recombinant human hyaluronidase (hylenex), utilizing commonly used angiocatheter gauges and button delivery systems. The safety and tolerability of hylenex-augmented SC infusion of LR through these delivery systems is also being evaluated.
Interventions
DRUGhylenex-facilitated subcutaneous Lactated Ringer's infusion
single subcutaneous 150 U dose of hylenex, followed by subcutaneous infusion of 1000 mL Lactated Ringer's solution
Sponsors
Halozyme Therapeutics
Baxter Healthcare Corporation
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* male or female, aged 18 to 60 years * intact normal skin without potentially obscuring features on both anterior thighs in the area intended for infusion * agreeing to no fluid intake for 12 hours prior to start of study infusion * vital signs within normal range or, if outside normal range, deemed not clinically significant * metabolic panel, hematology, virology and standard 10-test urine dipstick tests within normal range, or if outside normal range, deemed not clinically significant * if female of child-bearing potential,negative serum pregnancy tests * negative urine drug screens * written informed consent for participation
Exclusion criteria
* lower extremity edema * lower extremity pathology that could interfere with study outcome * history of cardiovascular disease * rales on lung auscultation * known allergy to hyaluronidase or other ingredient in the formulation of hylenex * pregnancy or breast-feeding a child * exposure to any experimental drug within 30 days prior to study participation * previous participation in this study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Technical Challenges | throughout subcutaneous hylenex and fluid administration period (continuous) | Protocol-specified challenges encountered during subcutaneous (SC) hylenex administration and/or SC infusion of Lactated Ringer's solution, including SC catheter kinking, catheter/button dislodgement, catheter/button pull-out, infusion pump alarm, other pump failure, healthcare provider intervention to secure/maintain SC infusion eg, re-taping, catheter/button manipulation, etc, and any other type of technical challenge encountered |
Secondary
| Measure | Time frame |
|---|---|
| Attempts Needed to Successfully Place Subcutaneous Catheter/Button | from start of first attempt until completion of catheter/button placement |
| Time Needed to Successfully Place Subcutaneous Catheter/Button | from start of first attempt until completion of catheter/button placement |
| Time Required to Infuse 1000 mL Fluid | from start of Lactated Ringer's (LR) infusion until 1000 mL LR infused |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Tegaderm-secured 24 ga Teflon Catheter | 10 |
| Tape-secured 24 ga Teflon Catheter | 11 |
| Tegaderm-secured 24 ga Polyurethane Catheter | 11 |
| Tape-secured 24 ga Polyurethane Catheter | 10 |
| Tegaderm-secured 20 ga Teflon Catheter | 12 |
| Tape-secured 20 ga Teflon Catheter | 12 |
| Tegaderm-secured 20 ga Polyurethane Catheter | 12 |
| Tape-secured 20 ga Polyurethane Catheter | 11 |
| SC Button With 27 ga X 9 mm Needle | 11 |
| Total | 100 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 | FG002 | FG003 | FG004 | FG005 | FG006 | FG007 | FG008 |
|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study | Lost to Follow-up | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Baseline characteristics
| Characteristic | SC Button With 27 ga X 9 mm Needle | Tape-secured 20 ga Polyurethane Catheter | Tegaderm-secured 20 ga Polyurethane Catheter | Tape-secured 20 ga Teflon Catheter | Tegaderm-secured 20 ga Teflon Catheter | Tape-secured 24 ga Polyurethane Catheter | Tegaderm-secured 24 ga Polyurethane Catheter | Tape-secured 24 ga Teflon Catheter | Tegaderm-secured 24 ga Teflon Catheter | Total |
|---|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical Between 18 and 65 years | 11 Participants | 11 Participants | 12 Participants | 12 Participants | 12 Participants | 10 Participants | 11 Participants | 11 Participants | 10 Participants | 100 Participants |
| Age Continuous | 36.6 years STANDARD_DEVIATION 12.3 | 32.4 years STANDARD_DEVIATION 12.7 | 33.6 years STANDARD_DEVIATION 10.7 | 34.3 years STANDARD_DEVIATION 10.3 | 34.0 years STANDARD_DEVIATION 12.5 | 35.3 years STANDARD_DEVIATION 10.9 | 33.8 years STANDARD_DEVIATION 10.4 | 36.0 years STANDARD_DEVIATION 10.6 | 34.6 years STANDARD_DEVIATION 9.39 | 34.5 years STANDARD_DEVIATION 10.8 |
| Region of Enrollment United States | 11 participants | 11 participants | 12 participants | 12 participants | 12 participants | 10 participants | 11 participants | 11 participants | 10 participants | 100 participants |
| Sex: Female, Male Female | 5 Participants | 4 Participants | 5 Participants | 6 Participants | 3 Participants | 3 Participants | 8 Participants | 1 Participants | 3 Participants | 38 Participants |
| Sex: Female, Male Male | 6 Participants | 7 Participants | 7 Participants | 6 Participants | 9 Participants | 7 Participants | 3 Participants | 10 Participants | 7 Participants | 62 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk | EG004 affected / at risk | EG005 affected / at risk | EG006 affected / at risk | EG007 affected / at risk | EG008 affected / at risk |
|---|---|---|---|---|---|---|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — | — / — | — / — | — / — | — / — | — / — | — / — | — / — |
| other Total, other adverse events | 6 / 10 | 5 / 11 | 9 / 11 | 7 / 10 | 9 / 12 | 10 / 12 | 10 / 12 | 10 / 11 | 8 / 11 |
| serious Total, serious adverse events | 0 / 10 | 0 / 11 | 0 / 11 | 0 / 10 | 1 / 12 | 0 / 12 | 0 / 12 | 0 / 11 | 0 / 11 |
Outcome results
Primary
Technical Challenges
Protocol-specified challenges encountered during subcutaneous (SC) hylenex administration and/or SC infusion of Lactated Ringer's solution, including SC catheter kinking, catheter/button dislodgement, catheter/button pull-out, infusion pump alarm, other pump failure, healthcare provider intervention to secure/maintain SC infusion eg, re-taping, catheter/button manipulation, etc, and any other type of technical challenge encountered
Time frame: throughout subcutaneous hylenex and fluid administration period (continuous)
Population: ITT (all treated subjects)
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Tegaderm-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with 2 Technical Challenges | 0 participants |
| Tegaderm-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with Catheter Dislodgement | 0 participants |
| Tegaderm-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with Infusion Pump Alarm | 2 participants |
| Tegaderm-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with at Least One Technical Challenge | 2 participants |
| Tegaderm-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with 3 Technical Challenges | 0 participants |
| Tegaderm-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with No Technical Challenges | 8 participants |
| Tegaderm-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with Catheter Pulled Out | 0 participants |
| Tegaderm-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with Catheter Kinking | 0 participants |
| Tegaderm-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with Infusion Pump Failure | 0 participants |
| Tegaderm-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with 1 TEchnical Challenge | 2 participants |
| Tape-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with Catheter Kinking | 1 participants |
| Tape-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with 1 TEchnical Challenge | 3 participants |
| Tape-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with Infusion Pump Failure | 0 participants |
| Tape-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with No Technical Challenges | 8 participants |
| Tape-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with Infusion Pump Alarm | 2 participants |
| Tape-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with Catheter Dislodgement | 0 participants |
| Tape-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with at Least One Technical Challenge | 3 participants |
| Tape-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with 3 Technical Challenges | 0 participants |
| Tape-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with 2 Technical Challenges | 0 participants |
| Tape-secured 24 ga Teflon Catheter | Technical Challenges | Subjects with Catheter Pulled Out | 0 participants |
| Tegaderm-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with 2 Technical Challenges | 0 participants |
| Tegaderm-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with Catheter Dislodgement | 0 participants |
| Tegaderm-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with Infusion Pump Failure | 0 participants |
| Tegaderm-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with No Technical Challenges | 9 participants |
| Tegaderm-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with 1 TEchnical Challenge | 2 participants |
| Tegaderm-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with at Least One Technical Challenge | 2 participants |
| Tegaderm-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with Infusion Pump Alarm | 2 participants |
| Tegaderm-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with Catheter Pulled Out | 0 participants |
| Tegaderm-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with 3 Technical Challenges | 0 participants |
| Tegaderm-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with Catheter Kinking | 0 participants |
| Tape-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with No Technical Challenges | 8 participants |
| Tape-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with Catheter Kinking | 2 participants |
| Tape-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with 3 Technical Challenges | 1 participants |
| Tape-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with Catheter Pulled Out | 0 participants |
| Tape-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with at Least One Technical Challenge | 2 participants |
| Tape-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with Catheter Dislodgement | 1 participants |
| Tape-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with 2 Technical Challenges | 0 participants |
| Tape-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with Infusion Pump Failure | 0 participants |
| Tape-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with 1 TEchnical Challenge | 1 participants |
| Tape-secured 24 ga Polyurethane Catheter | Technical Challenges | Subjects with Infusion Pump Alarm | 1 participants |
| Tegaderm-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with Infusion Pump Failure | 0 participants |
| Tegaderm-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with at Least One Technical Challenge | 2 participants |
| Tegaderm-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with 2 Technical Challenges | 0 participants |
| Tegaderm-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with No Technical Challenges | 10 participants |
| Tegaderm-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with Catheter Pulled Out | 0 participants |
| Tegaderm-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with Catheter Kinking | 0 participants |
| Tegaderm-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with Infusion Pump Alarm | 2 participants |
| Tegaderm-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with 3 Technical Challenges | 0 participants |
| Tegaderm-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with Catheter Dislodgement | 0 participants |
| Tegaderm-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with 1 TEchnical Challenge | 2 participants |
| Tape-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with 2 Technical Challenges | 0 participants |
| Tape-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with at Least One Technical Challenge | 2 participants |
| Tape-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with No Technical Challenges | 10 participants |
| Tape-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with 1 TEchnical Challenge | 2 participants |
| Tape-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with 3 Technical Challenges | 0 participants |
| Tape-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with Catheter Kinking | 0 participants |
| Tape-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with Catheter Dislodgement | 0 participants |
| Tape-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with Catheter Pulled Out | 0 participants |
| Tape-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with Infusion Pump Alarm | 2 participants |
| Tape-secured 20 ga Teflon Catheter | Technical Challenges | Subjects with Infusion Pump Failure | 0 participants |
| Tegaderm-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with Infusion Pump Failure | 0 participants |
| Tegaderm-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with No Technical Challenges | 9 participants |
| Tegaderm-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with 3 Technical Challenges | 0 participants |
| Tegaderm-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with at Least One Technical Challenge | 3 participants |
| Tegaderm-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with 1 TEchnical Challenge | 3 participants |
| Tegaderm-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with Catheter Pulled Out | 0 participants |
| Tegaderm-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with 2 Technical Challenges | 0 participants |
| Tegaderm-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with Catheter Kinking | 0 participants |
| Tegaderm-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with Infusion Pump Alarm | 3 participants |
| Tegaderm-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with Catheter Dislodgement | 0 participants |
| Tape-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with Infusion Pump Alarm | 1 participants |
| Tape-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with at Least One Technical Challenge | 2 participants |
| Tape-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with Catheter Kinking | 2 participants |
| Tape-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with Catheter Pulled Out | 1 participants |
| Tape-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with 3 Technical Challenges | 0 participants |
| Tape-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with 1 TEchnical Challenge | 0 participants |
| Tape-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with Catheter Dislodgement | 0 participants |
| Tape-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with No Technical Challenges | 9 participants |
| Tape-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with Infusion Pump Failure | 0 participants |
| Tape-secured 20 ga Polyurethane Catheter | Technical Challenges | Subjects with 2 Technical Challenges | 2 participants |
| SC Button With 27 ga X 9 mm Needle | Technical Challenges | Subjects with Infusion Pump Failure | 0 participants |
| SC Button With 27 ga X 9 mm Needle | Technical Challenges | Subjects with Catheter Dislodgement | 0 participants |
| SC Button With 27 ga X 9 mm Needle | Technical Challenges | Subjects with 2 Technical Challenges | 0 participants |
| SC Button With 27 ga X 9 mm Needle | Technical Challenges | Subjects with Catheter Pulled Out | 0 participants |
| SC Button With 27 ga X 9 mm Needle | Technical Challenges | Subjects with 1 TEchnical Challenge | 3 participants |
| SC Button With 27 ga X 9 mm Needle | Technical Challenges | Subjects with No Technical Challenges | 8 participants |
| SC Button With 27 ga X 9 mm Needle | Technical Challenges | Subjects with Infusion Pump Alarm | 3 participants |
| SC Button With 27 ga X 9 mm Needle | Technical Challenges | Subjects with 3 Technical Challenges | 0 participants |
| SC Button With 27 ga X 9 mm Needle | Technical Challenges | Subjects with at Least One Technical Challenge | 3 participants |
| SC Button With 27 ga X 9 mm Needle | Technical Challenges | Subjects with Catheter Kinking | 0 participants |
Secondary
Attempts Needed to Successfully Place Subcutaneous Catheter/Button
Time frame: from start of first attempt until completion of catheter/button placement
Population: ITT (all treated subjects)
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Tegaderm-secured 24 ga Teflon Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 2 Attempts | 0 participants |
| Tegaderm-secured 24 ga Teflon Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 1 Attempt | 10 participants |
| Tape-secured 24 ga Teflon Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 2 Attempts | 0 participants |
| Tape-secured 24 ga Teflon Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 1 Attempt | 11 participants |
| Tegaderm-secured 24 ga Polyurethane Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 1 Attempt | 10 participants |
| Tegaderm-secured 24 ga Polyurethane Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 2 Attempts | 1 participants |
| Tape-secured 24 ga Polyurethane Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 2 Attempts | 0 participants |
| Tape-secured 24 ga Polyurethane Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 1 Attempt | 10 participants |
| Tegaderm-secured 20 ga Teflon Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 1 Attempt | 12 participants |
| Tegaderm-secured 20 ga Teflon Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 2 Attempts | 0 participants |
| Tape-secured 20 ga Teflon Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 1 Attempt | 11 participants |
| Tape-secured 20 ga Teflon Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 2 Attempts | 1 participants |
| Tegaderm-secured 20 ga Polyurethane Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 2 Attempts | 0 participants |
| Tegaderm-secured 20 ga Polyurethane Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 1 Attempt | 12 participants |
| Tape-secured 20 ga Polyurethane Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 1 Attempt | 11 participants |
| Tape-secured 20 ga Polyurethane Catheter | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 2 Attempts | 0 participants |
| SC Button With 27 ga X 9 mm Needle | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 2 Attempts | 0 participants |
| SC Button With 27 ga X 9 mm Needle | Attempts Needed to Successfully Place Subcutaneous Catheter/Button | 1 Attempt | 11 participants |
Secondary
Time Needed to Successfully Place Subcutaneous Catheter/Button
Time frame: from start of first attempt until completion of catheter/button placement
Population: ITT (all treated subjects)
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| Tegaderm-secured 24 ga Teflon Catheter | Time Needed to Successfully Place Subcutaneous Catheter/Button | 23 seconds |
| Tape-secured 24 ga Teflon Catheter | Time Needed to Successfully Place Subcutaneous Catheter/Button | 43 seconds |
| Tegaderm-secured 24 ga Polyurethane Catheter | Time Needed to Successfully Place Subcutaneous Catheter/Button | 30 seconds |
| Tape-secured 24 ga Polyurethane Catheter | Time Needed to Successfully Place Subcutaneous Catheter/Button | 34 seconds |
| Tegaderm-secured 20 ga Teflon Catheter | Time Needed to Successfully Place Subcutaneous Catheter/Button | 30 seconds |
| Tape-secured 20 ga Teflon Catheter | Time Needed to Successfully Place Subcutaneous Catheter/Button | 49 seconds |
| Tegaderm-secured 20 ga Polyurethane Catheter | Time Needed to Successfully Place Subcutaneous Catheter/Button | 31 seconds |
| Tape-secured 20 ga Polyurethane Catheter | Time Needed to Successfully Place Subcutaneous Catheter/Button | 15 seconds |
| SC Button With 27 ga X 9 mm Needle | Time Needed to Successfully Place Subcutaneous Catheter/Button | 9 seconds |
Secondary
Time Required to Infuse 1000 mL Fluid
Time frame: from start of Lactated Ringer's (LR) infusion until 1000 mL LR infused
Population: ITT (all treated subjects)
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Tegaderm-secured 24 ga Teflon Catheter | Time Required to Infuse 1000 mL Fluid | 6.82 hours | Standard Deviation 0.058 |
| Tape-secured 24 ga Teflon Catheter | Time Required to Infuse 1000 mL Fluid | 6.78 hours | Standard Deviation 0.098 |
| Tegaderm-secured 24 ga Polyurethane Catheter | Time Required to Infuse 1000 mL Fluid | 6.81 hours | Standard Deviation 0.013 |
| Tape-secured 24 ga Polyurethane Catheter | Time Required to Infuse 1000 mL Fluid | 6.80 hours | Standard Deviation 0.114 |
| Tegaderm-secured 20 ga Teflon Catheter | Time Required to Infuse 1000 mL Fluid | 6.78 hours | Standard Deviation 0.071 |
| Tape-secured 20 ga Teflon Catheter | Time Required to Infuse 1000 mL Fluid | 6.80 hours | Standard Deviation 0.013 |
| Tegaderm-secured 20 ga Polyurethane Catheter | Time Required to Infuse 1000 mL Fluid | 6.81 hours | Standard Deviation 0.078 |
| Tape-secured 20 ga Polyurethane Catheter | Time Required to Infuse 1000 mL Fluid | 6.79 hours | Standard Deviation 0.108 |
| SC Button With 27 ga X 9 mm Needle | Time Required to Infuse 1000 mL Fluid | 6.82 hours | Standard Deviation 0.078 |