Transbronchial Catheter Aspiration and Transbronchial Needle Aspiration in the Diagnosis of Lung Cancer

Transbronchial Catheter Aspiration Compared to Transbronchial Needle Aspiration in the Diagnosis of Peripheral Nodules and Masses of the Lung

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00807391

Enrollment

Registered

2008-12-11

Start date

2009-07-31

Completion date

2010-11-30

Last updated

2011-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer

Keywords

lung cancer, transbronchial biopsy, transbronchial catheter aspiration, transbronchial needle aspiration, peripheral pulmonary lesion, bronchoscopy

Brief summary

The aim of this study is prospectively to determine the diagnostic sensitivity of Transbronchial Catheter Aspiration (TBCA) in comparison with Transbronchial Needle Aspiration (TBNA) in the diagnosis of peripheral nodules and masses of the lung.

Detailed description

The yield of transbronchial forceps biopsy under fluoroscopy in the diagnosis of peripheral lesion of the lung lies between 32 and 57%. Several studies prove an amelioration of success rates by addition of cytological methods such as TBNA, TBCA and bronchial brushing. Furthermore, for TBNA and TBCA a significantly higher yield was reported in comparison with transbronchial forceps biopsy. TBNA and TBCA are routinely used methods, both techniques are safe, the instruments used are certificated.

Interventions

PROCEDURETBCA, TBNA

One arm, in random order first transbronchial catheter aspiration and second transbronchial needle aspiration or vice verse, both techniques routinely used in the diagnosis of peripheral pulmonary lesions; the cytological specimens of TBCA and TBNA are in random order examined by two independent cytologists, all cytological specimens are afterwards examined by a third, supervising cytologist.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* informed consent prior to the procedure * radiologically peripheral pulmonary lesions between 10 and 60 millimeters in diameter

Exclusion criteria

* endoscopically visible lung carcinoma * no consent in further diagnostic procedures, when bronchoscopy fails to establish a diagnosis * haemorrhagic syndrome; grave cardiac disease; oxygen saturation lower than 90 percent

Design outcomes

Primary

Measure	Time frame
Diagnostic sensitivity of transbronchial catheter aspiration in comparison with transbronchial needle aspiration.	one year

Secondary

Measure	Time frame
Yield by combination of the applied techniques	one year

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026