Diastolic Dysfunction
Conditions
Keywords
Aging, Diastolic dysfunction, Systolic function, Exercise, Echocardiography, tissue Doppler imaging, Cardiac function
Brief summary
The purpose of this study is to determine the effect of aerobic interval training on left- and right ventricular diastolic- and systolic function on healthy, sedate people over 70 years. The old sedate cohort will be compared to young, sedate subjects also performing aerobic interval training and old master athletes without intervention.
Detailed description
Aging is associated with a reduced diastolic and systolic function of the heart. Earlier studies have shown that physical exercise can improve both systolic and diastolic function. However the impact on age-related cardiac function is to some extent conflicting. The use of different training intensities will impact on the cardiac result. We have in earlier studies shown aerobic interval training at 90 % of maximal heart rate (4x4 minutes) to have more impact on cardiac function, endothelial function and maximal oxygen uptake compared to moderate intensity. To our knowledge the effect of aerobic interval training on cardiac function has not been studied in an old, sedate group before.
Interventions
High intensity aerobic interval training consists of 10 minutes warm up at \ 60% of maximal heart rate, 4x4 minutes intervals at 90-95 % of maximal heart rate corresponding to 85-90% of VO2max) walking/running uphill on a treadmill, with three minutes active pause between the exercise bouts at 60-70% maximal heart rate. The session is terminated with 3 minutes cool down. Total exercise time is 38 minutes.The training is supervised by an exercise physiologist and the subjects train 3 times per week for 12 weeks.
Sponsors
Norwegian University of Science and Technology
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* over 70 years, healthy * not exercising more than twice per week
Exclusion criteria
* chronic illness * chronic use of any medication * regular smoking * metabolic or cardiovascular diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of left and right ventricular early diastolic tissue velocity at rest and sub maximal exercise ,e'. | 12 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of left and right ventricular systolic tissue velocity function at rest and sub maximal exercise, S'. | 12weeks |
Countries
Norway
Outcome results
None listed