Cystic Fibrosis With Other Manifestations, Sinusitis
Conditions
Brief summary
Aim of the study is to detect the prevalence of chronic rhinosinusitis, pathogen colonization of the lower and upper airways and, in a sub-cohort the sense of smelling in patients with cystic fibrosis.
Detailed description
The sub-study on the sense of smelling in CF has been finalized in the meantime. Results were published in 2012: Smell in cystic fibrosis. Lindig J, Steger C, Beiersdorf N, Michl R, Beck JF, Hummel T, Mainz JG. Eur Arch Otorhinolaryngol. 2013 Mar;270(3):915-21. doi: 10.1007/s00405-012-2124-2. Epub 2012 Aug 14.
Interventions
OTHERnasal lavage and sputum collection
non-invasive longitudinal assessment of pathogen colonization in both airway levels
Sponsors
University of Jena
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Subject has a confirmed diagnosis of cystic fibrosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dynamics in CF upper and lower airway colonization with pathogens | 10 years | longitudinal non-invasive sampling of upper and lower airways in CF |
| Assessment of ability to smell in CF patients | 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| pulmonary function / BMI | 10 years |
Countries
Germany
Contacts
Primary ContactJochen Mainz, MD
Outcome results
None listed