Dose, Effects and Characteristics of Pilocarpine

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00803803

Enrollment

Registered

2008-12-08

Start date

1978-08-31

Completion date

1979-12-31

Last updated

2016-11-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Open-angle Glaucoma

Keywords

Pilocarpine, POAG, IOP, Concentration, Frequency, Primary open-angle glaucoma, Primary open-angle glaucoma suspect

Brief summary

The purpose of this investigation, in which pilocarpine was given in repeated doses, was to evaluate: Part I - the effects of different concentrations of pilocarpine hydrochloride on intraocular pressure. Part II -the effects on intraocular pressure of glaucomatous patients to pilocarpine 2% when given once, twice and four daily. In addition, we studied various attributes of the eye which may serve as indicators of responsiveness of individual patients to pilocarpine.

Detailed description

In addition, we studied various attributes of the eye which may serve as indicators of responsiveness of individual patients to pilocarpine.

Interventions

DRUGPilocarpine Concentration

Varying concentration 0.5 to 8%

DRUGPilocarpine Frequency

1 to 4 times daily

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Primary open-angle glaucoma * Primary open-angle glaucoma suspect

Design outcomes

Primary

Measure	Time frame
Intraocular Pressure	25 days

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026