Knee Arthroscopy
Conditions
Keywords
spinal anesthesia, mepivacaine, fentanyl, duration of anesthesia, knee arthroscopy, regional anesthesia, Spinal anesthesia for knee arthroscopy
Brief summary
The purpose of this study is to determine if the addition of intrathecal fentanyl to low dose mepivacaine spinal anesthesia provides adequate surgical anesthesia with shorter duration of motor blockade. It is hypothesized that lower doses of spinal mepivacaine when combined with fentanyl will result in adequate surgical block for knee arthroscopy surgery with faster recovery and discharge compared to mepivacaine alone.
Interventions
DRUGMepivacaine without fentanyl
45 mg 1.5% mepivacaine injection for spinal anesthesia
DRUGMepivacaine with Fentanyl
10 micrograms fentanyl with 30 mg 1.5% mepivacaine injection for spinal anesthesia
Sponsors
University Health Network, Toronto
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Patients having unilateral arthroscopic surgery of the knee; 2. ASA I-III status; 3. Age 18-80 years; 4. BMI\< 35.
Exclusion criteria
1. Patients who have previous history of hypersensitivity to local anesthetics or contraindications for spinal anesthesia (i.e. bleeding diathesis, coagulopathy); 2. Patients with radiating low back pain and neurological deficits in lower extremities; 3. Patients who are incapable of giving an informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to complete motor block regression (0) as measured by modified Bromage scale. | Every 2 minutes from administration of the spinal until complete onset. |
Secondary
| Measure | Time frame |
|---|---|
| Block success, peak, and duration; time to ambulation, urination, discharge; incidence of adverse events. | Up to 72 hours after surgery. |
Countries
Canada
Outcome results
None listed