Port Wine Stain
Conditions
Keywords
hypervascular anomalies
Brief summary
The purpose of this study is to improve port wine stain therapeutic outcome in response to laser therapy. The researchers want to determine whether the combined use of pulsed dye laser therapy and rapamycin will improve PWS therapeutic outcome.
Detailed description
The researchers want to combined use of pulsed dye laser to induce port wine stain blood vessel injury, and rapamycin directly inhibits the proliferation of vascular endothelial cells driven by vascular endothelial growth factor which preventing port wine stain angiogenesis and recanalization, to improve port wine stain lesion blanching.
Interventions
DRUGRapamycin Treatment of Port Wine Stain
Treatment of Port Wine Stain
Sponsors
Pfizer
Beckman Laser Institute University of California Irvine
University of California, Irvine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* port wine stain birthmarks suitable for comparison testing.
Exclusion criteria
* Pregnancy. * Abnormal blood hematology or chemistry blood tests or urine analysis. * History of cancer, History of high cholesterol, lipids or liver disease * Allergy to macrolide drugs (e.g., erythromycin). * Any therapy within the previous two months to the proposed PWS treatment sites. * Concurrent use of known photosensitizing drugs,immunosuppressive drugs or systemic steroids,antifungals, antiepileptics, HIV protease inhibitors, cimetidine, cisapride, clarithromycin, dannzol, diltiazem, erythromycin, metoclopramide, rifabutin, rifampin, rifapentine, troleandomycin, or verapamil.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| improve port wine stain (PWS) therapeutic outcome | 8 weeks |
Countries
United States
Outcome results
None listed