Postoperative Pain
Conditions
Brief summary
The purpose of this study is to determine if dynamic psychophysical testing along with genetic screening will allow to identify pre-operatively women who will suffer severe acute pain post-operatively and the subset who may experience chronic pain following cesarean section.
Interventions
OTHERPsychophysical testing, questionnaires, and genetics
pre-operative psychophysical testing of endogenous pain modulation, pre-operative questionnaires, peri- and post-operative data collection, long term follow-up assessing chronic pain, SNP association analysis, and whole genome scanning association studies
Sponsors
University of Washington
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Women age 18-50 scheduled for an elective cesarean section (1st or 2nd cesarean section)
Exclusion criteria
Women who: * have taken opioids, acetaminophen, or NSAIDs 48 hrs prior to psychophysical testing * have had more than two previous cesarean sections * have a vertical abdominal incision from a prior cesarean section * are non-English speaking * have mental health issues * have a failure of spinal anesthetic and require conversion to general anesthesia * have a vertical uterine incision performed during ongoing cesarean section * have a previous vertical uterine scar discovered during ongoing cesarean section
Countries
Belgium, Brazil, Singapore, United States
Contacts
Primary ContactLisa Y Flint, BS
Backup ContactKatrina L Golub, MPH
Outcome results
None listed