Valve Surgery, Coronary Artery Bypass Grafting
Conditions
Keywords
aorta valve, mitral valve, coronary artery bypass grafting surgery, perfusion, priming
Brief summary
The use of Tetraspan® as prime solution can reduce fluid extravasation after perfusion versus Ringer acetate. Plasma-adapted HES-solutions produce also less acidosis.
Detailed description
Fifty patients scheduled for elective primary and single cardiac surgery include in this prospective study. Patients with preoperative coagulation disorders, or renal or hepatic failure, are excluded. Before admission to the operation theatre, the patients allocate in random order to receive one of the following solutions during the extracorporeal circulation: 1. Ringer-acetate solution 2. 6% HES solution (Tetraspan®) During the 1 postoperative day we register hemodynamic changes, fluid balance, fluid extravasation, plasma ion concentration, modified thromboelastography, and kidney function.
Interventions
DRUGHES
20ml/kg as prime fluid
DRUGRinger lactate
Sponsors
B. Braun Melsungen AG
University of Helsinki
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Elective combined cardiac surgery
Exclusion criteria
* Liver failure * Kidney failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fluid balance | 1 postoperative day |
Countries
Finland
Outcome results
None listed