Arthroplasty, Replacement, Hip
Conditions
Keywords
Ketamine, Morphine, PCA, Hyperalgesia, Nor-ketamine
Brief summary
Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that ketamine administrated separately via a continuous infusion, could induced a better analgesic effect. We will perform a randomised double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion.
Detailed description
Double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion
Interventions
Ketamine bolus preoperative and syringe pump peroperative, and morphine postoperative (PCA)
DRUGMorphine
Bolus preoperative of NaCl and syringe pump peroperative of NaCl, and morphine postoperative (PCA)
DRUGPostoperative PCA of Ketamine and morphine
Bolus preoperative of NaCl and syringe pump peroperative of Ketamine, and morphine postoperative (PCA)
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* total hip arthroplasty
Exclusion criteria
* pre operative opioid administration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphine consumption in PACU and in hospitalisation room | at 24 and 48 hours |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative Visual Analogic Score of pain | in Recovery Room, at 24 and 48 hours, in the ward |
| Postoperative Measure of mechanical hyperalgesia by Von Frey filament device | 24 and 48 hours in the ward |
| Postoperative measure Ketamine and Nor-Ketamine blood levels | at 24 and 48 hours in the ward |
Countries
France
Outcome results
None listed