Endometrial Injury and IVF-ET Outcome

Does Endometrial Injury in the Non-Transfer Cycle Improve the IVF-ET Outcome in the Subsequent Cycle in Patients With Previous Failed IVF Cycles: A Randomized Control Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00796341

Enrollment

Registered

2008-11-24

Start date

2007-11-30

Completion date

2008-09-30

Last updated

2008-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

invitro-fertilization ,embryo transfer,endometrial injury

Brief summary

Implantation of the human embryo is the limiting factor in the success of invitro-fertilization and embryo transfer(IVF-ET).We wanted to find out whether creating a local injury to the endometrium in the non-transfer cycle would improve the IVF-ET outcome in the subsequent cycle.We believe that the injury created causes release of substances which help in implantation.

Detailed description

Study Design and Subjects: This is a randomized control study designed to evaluate the effect of local injury to the endometrium in non-transfer cycle in patients with previous failed IVF. Patients will be randomly allotted to control and intervention group The patients in the intervention group Pipelle endometrial sampling 7-10th day and 24-26th day in the cycle prior to IVF transfer cycle. Outcome Measures: Clinical pregnancy rate,implantation rate and ongoing pregnancy rate. SAMPLE SIZE: 100 PATIENTS (50 in each group).

Interventions

PROCEDUREPIPELLE ENDOMETRIAL SAMPLING

Pipelle endometrial sampling will be done twice between 7th to 10th day and 24th to 26th d in the cycle prior to IVF.

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 37 Years

Healthy volunteers

Inclusion criteria

* Previous failed In-vitro fertilization embryo transfer cycle * Patients who are good responders and have good quality embryos in the previous attempts * Age of patients upto 37yrs

Exclusion criteria

* Those detected to have endometrial tuberculosis in the past, including those treated with Antituberculosis treatment * Those with intramural fibroid distorting the endometrial cavity/sub-mucous myoma * Those with sonographically detected hydrosalpinx

Design outcomes

Primary

Measure	Time frame
PRIMARY OUTCOME MEASURE:IMPLANTATION RATE;	9 MONTHS

Secondary

Measure	Time frame
CLINICAL PREGNANCY RATE,ONGOING PREGNANCY RATE	9 MONTHS

Countries

India

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026