Intracranial Hypertension, Traumatic Brain Injury
Conditions
Brief summary
Will an increase of the dose of mannitol improve the effects on neuromonitoring in patients suffering intracranial hypertension following traumatic brain injury?
Detailed description
traumatic brain injury intracranial hypertension 0,4 g/ kg vs 0,8 g/ kg (randomized) on 20 minutes monitoring: ICP, transcranial doppler, brain pO2, MAP, HR, diuresis, biology duration: 2 hours
Interventions
DRUGvariation of mannitol dose
in case of intracranial hypertension up to 20 mmHg lasting more than 10 minutes and without nociceptive stimulation or systemic instability: injection of either 0.4 g/ kg or 0.8 g/ kg of mannitol 20% (randomized) on 20 minutes, with monitoring of neurologic, systemic and biologic datas during 120 minutes
Sponsors
University Hospital, Grenoble
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* adults * severe traumatic brain injury * intracranial hypertension requiring mannitol administration
Exclusion criteria
* impeding neurosurgery * hemodynamic or respiratory severe failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intracranial pressure | 2 hours |
Secondary
| Measure | Time frame |
|---|---|
| brain PO2 | 2h |
| MAP | 2h |
| Heart Rate | 2h |
| transcranial doppler | 2 h |
| diuresis | 2h |
| fluid requirement | 2h |
| biology (blood gases, natremia, hematocrit) | 2h |
Countries
France
Outcome results
None listed