Bronchial Hyperreactivity in Atopic Dermatitis Patients - a 10 Year Follow-up

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00795496

Enrollment

Registered

2008-11-21

Start date

2008-11-30

Completion date

2010-08-31

Last updated

2011-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atopic Dermatitis

Keywords

Atopic dermatitis, Bronchial hyperreactivity, Skin prick tests, Serum IgE, Mantoux test

Brief summary

The investigators will contact 64 patients with atopic dermatitis (AD) who participated in a long-term tacrolimus ointment trial in Helsinki 10 years ago, and ask them to participate in this follow-up study. The investigators will do the same tests as 10 years ago, i.e. bronchial hyperreactivity, skin prick tests, serum-IgE, Mantoux-test (2 TU), and questionnaires about asthma and allergic rhinitis symptoms. The investigators also collect data about their AD medication during the last 10 years. The investigators hypothesis is that when the skin condition improves in patients with AD the brochial hyperreactivity improves. The investigators also want to study whether different treatments play a role in the development or resolution of bronchial hyperreactivity.

Detailed description

We will by letters and telephone contact all patients (n=64) who fulfill the inclusion criteria for this study. The testing in the study (bronchial hyperreactivity, skin prick testing, serum IgE) is cross-sectional, but we retrospectively collect data from the last 10 years about the skin condition and medication for atopic diseases.

Interventions

PROCEDUREHistamine provocation

A dosimetric histamine challenge test in which the provocative dose of inhaled histamine producing a decrease of 15% in FEV1 is measured.

PROCEDURESkin prick tests

Skin prick testing will be performed for: birch, timothy, mugwort, alder, pine, cat, dog, horse, house dust mite, Cladosporium herbarum.

PROCEDURESerum IgE blood testing

One blood test to measure total serum IgE

PROCEDUREMantoux-testing

Tuberculin (2 TU) s.c. on the forearm. The test is read after 72 hours.

Study design

Observational model

COHORT

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patient has participated in the FG-506-06-21 study in Helsinki * Patient was tested for bronchial hyperreactivity in the years 1998-2000 * Patient gives signed informed consent to participate in this study

Design outcomes

Primary

Measure	Time frame
Bronchial hyperreactivity	10 year follow-up

Secondary

Measure	Time frame
Skin prick tests	10 year follow-up
Serum-IgE	10-year follow-up
Mantoux-test	72 hours

Countries

Finland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026