Abortion, Curettage
Conditions
Keywords
Opioids, General anesthesia
Brief summary
Uterine curettage is usually performed under the anesthesia of propofol-fentanyl or para-cervical block,of which generally has significant incidence of respiratory depression which increases the demand on intraoperative monitoring, or has unavoidable insufficient blockade which results in intraoperative suffering of pain. Butorphanol is an analgesic with combined effects on mu and kappa opioid receptors leading to a role as analgesia and sedation. The investigators hypothesized that combined propofol with butorphanol during uterine curettage would produce optimal effectiveness of these two drugs by adding sedative and analgesic effects together. In addition, it would decrease the intraoperative consumption of propofol without increase the incidence of side effects. Furthermore, such combination would alleviate postoperative pain.
Interventions
DRUGFentanyl Citrate
Combined anesthesia with propofol (2-2.5mg/kg) and fentanyl (5 μg)
Combined anesthesia with propofol (2-2.5 mg/kg) and butorphanol (1mg)
Sponsors
Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
19 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* ASA status I-II; * Performing abortion operation (medical- or drug-induced); * Requiring painless abortion;
Exclusion criteria
* \< 19yrs, and \>= 45yrs; * History of central active drugs administration; * Drug abuse; * Hypertension; * Diabetes; * Any other chronic diseases; * Allergy to the study drugs; * Habit of over-volume alcohol drinking; * Records of history of centrally active drug use and psychiatry; * Any organic disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative awareness | During the whole process of anesthesia |
Secondary
| Measure | Time frame |
|---|---|
| Bispectral Index (BIS) value | During the whole process of anesthesia |
| Anesthetic consumptions | From the start of operation to the end of surgical procedures |
| Postoperative pain | Since the end of the operation to 48 h follow-up. |
| Postoperative bleeding | Since the end of operation to 48 h follow-up |
Countries
China
Outcome results
None listed