Comparative Pain Control Between 0.2 or 0.3 Spinal Morphine and 0.25 or 0.5 % Bupivacaine for FNB After TKA

Comparative Effect of 0.2 or 0.3 Spinal Morphine and 0.25 or 0.5 % Bupivacaine for Femoral Nerve Block After Total Knee Replacement

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00795223

Enrollment

160

Registered

2008-11-21

Start date

2008-10-31

Completion date

2009-05-31

Last updated

2009-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Operative Pain, Total Knee Replacement

Brief summary

Comparative efficacy of 24 and 48 hours post operative pain control in single total knee replacement between intrathecal bupivacaine with 0.2 or 0.3 mg morphine together with 0.25 or 0.5 % bupivacaine for single femoral nerve block

Interventions

DRUGmorphine and bupivacaine

0.3 mg morphine for spinal together with 0.5% bupivacaine for femoral nerve block

DRUGspinal morphine and marcaine

0.3 mg spinal morphine together with 0.25% bupivacaine for femoral nerve block

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

45 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Single elective total knee replacement in ASA 1-3 without significant cardiovascular limitation

Exclusion criteria

* patient at risk in usage COX-2 for post operative pain control

Design outcomes

Primary

Measure	Time frame
Global assessment in post operative pain control	Begining of first enrollment in december 2008

Secondary

Measure	Time frame
Global assessment of post operative pain in 48 HOURS AND SIDE EFFECTS	first enrollment in December 2008

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026