Relation of Circulating Endothelium-derived Microparticle to Carotid Atherosclerosis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00795067

Enrollment

154

Registered

2008-11-21

Start date

2008-11-30

Completion date

2013-11-30

Last updated

2015-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis

Brief summary

The investigators hypothesized that circulating endothelium-derived microparticle (EMP) may be a useful surrogate marker of atherosclerosis and future episode of cerebrovascular events. Peripheral blood is drawn at the time of carotid ultrasound examination. Circulating EMPs are counted using flow-cytometry. The correlation among circulating EMP, ultrasound findings, and atherosclerotic risk factors are determined by multiple stepwise regression analysis. The prevalence of cerebrovascular events is also determined during 3-year follow-up period.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients who undergo carotid ultrasound examination for screening of atherosclerosis

Exclusion criteria

* Cerebrovascular events within the last 12 months * Acute coronary syndrome, coronary and peripheral intervention within the last 6 months * Uncontrolled heart failure * Other severe systemic diseases

Design outcomes

Primary

Measure	Time frame
The number of circulating EMPs	at the time of carotid ultrasound examination

Secondary

Measure	Time frame
The occurrence of cerebrovascular and/or cardiovascular events	3 years

Countries

Japan

Outcome results