Laparotomy Versus Percutaneous Puncture in Patients With Abdominal Compartment Syndrome During Acute Pancreatitis

Decompressive Laparotomy With Temporary Abdominal Closure Versus Percutaneous Puncture With Placement of Abdominal Catheter in Patients With Abdominal Compartment Syndrome During Acute Pancreatitis:Multicenter, Randomised, Controlled Study

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00793715

Acronym

DECOMPRESS

Enrollment

100

Registered

2008-11-19

Start date

2010-07-31

Completion date

2013-06-30

Last updated

2010-07-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Pancreatitis, Mortality

Keywords

acute pancreatitis, abdominal compartment syndrome, decompressive laparotomy, percutaneous abdominal puncture, Mortality of patients treated in both arms

Brief summary

Decompressive laparotomy with temporary abdominal closure, will decrease of overall mortality and major morbidity in patients with abdominal compartment syndrome during acute pancreatitis in comparison with percutaneous puncture with placement of abdominal catheter.

Detailed description

We anticipated that decompressive laparotomy with temporary abdominal closure, beside all potentially negative side effects that early open surgery carries in patients with acute pancreatitis, results in decrease of overall mortality and major morbidity. The DECOMPRESS study is designed to compare effects of decompressive laparotomy with temporary abdominal closure and percutaneous puncture with placement of abdominal catheter in patients with abdominal compartment syndrome during acute pancreatitis.

Interventions

PROCEDUREDecompressive laparotomy with temporary abdominal closure

Surgical intervention including midline incision with temporary abdominal closure and several planed staged relaparotomies

PROCEDUREPercutaneous puncture with placement of abdominal catheter

Installation of abdominal catheter percutaneously via abdominal centesis 2cm bellow the umbilicus

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* The study population consists of patients with acute pancreatitis complicated with development of abdominal compartment syndrome.

Exclusion criteria

* Patients will not be enrolled to the study if any of the following criteria will be present: * age \< 18 and \> 80 years * recent surgical interventions * psychoses * pregnancy * previously history of chronic pancreatitis

Design outcomes

Primary

Measure	Time frame
Mortality rate during the hospital stay for patients with abdominal compartment syndrome during acute pancreatitis.	2 years

Secondary

Measure	Time frame
development of a new organ failure	2 years
number of infectious complications,	2 years
duration time of organ failure	2 years
intensive care stay	2 years
total hospital stay	2 years
needs for necrosectomy,	2 years

Countries

Serbia

Contacts

Primary ContactIvana Teic, nurse

ivanateic@yahoo.com+381 11 366 2266

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026