Hemolysis
Conditions
Keywords
Morbid obesity, General anaesthesia, Propofol, Sevoflurane
Brief summary
The purpose of this study is to determine if propofol could protect erythrocytes by directly scavenging free radicals from the blood current and increasing resistance of their cell membranes in patients submitted to gastroplasty.
Interventions
DRUGPropofol
Patients in the Propofol Group (PG) will be induced with target-controlled infusion (TCI) of propofol (Diprifusor, AstraZeneca) and remifentanil (Asena PK, Cardinal Health) at the target dose of 6.0 µg.ml-1 and 8.0 ηg.ml-1, respectively. The patients in the Sevoflurane Group (SG) will be induced with remifentanil TCI at target dose of 8.0 ηg.ml-1 and etomidate 0.5 mg.kg-1 in bolus.
Sponsors
Centro Medico Campinas
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients between BMI 40-50 kg/m2
Exclusion criteria
* patients with BMI under 40 kg/m2 and over 50 kg/m2 * alcohol users * illicit-drug users * patients in regular use of anti-depressants, proton bomb inhibitors or calcium canal blockers * patients transfused either recently, during the intra-operative period or within 10 hours post-operative * patients previously known to be hypersensitive to any drug that is used during the study * patients with any psychiatric disorder or dementia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Count erythrocytes | After 10 hours post-surgery |
Secondary
| Measure | Time frame |
|---|---|
| Bilirubins(direct and indirect) | After 10 hours post-surgery |
Countries
Brazil
Outcome results
None listed