Analgesia
Conditions
Keywords
Anesthesia General, Anesthetics Inhalation, Stress measurement, Surgical Stress, Diagnostic Techniques and Procedures
Brief summary
The aim of the present prospective randomized study was to challenge the ability of SSI to detect painful stimulation during sevoflurane - remifentanil anesthesia.
Detailed description
General anesthesia can be considered as a combination of hypnosis, antinociception and immobility. Whereas monitoring of depth of hypnosis, and muscle relaxation can be regarded as accepted, determination of the nociception is based on clinical signs like somatic or autonomic responses. Recently, the multivariate surgical stress index (SSI)has been demonstrated to correlate with surgical stress intensity. Thus, SSI might be a useful variable to adjust analgesic drug administration in individual patients. We want to investigate whether SSI is able to indicate nociception following standardized noxious stimulation during balanced sevoflurane - remifentanil anesthesia.
Interventions
PROCEDUREstandardized pain stimulus
a tetanic stimulus (30s, 50 Hz, 60mA) applied as standardized pain stimulus
Sponsors
University Hospital Schleswig-Holstein
Study design
Allocation
RANDOMIZED
Primary purpose
DIAGNOSTIC
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* age between 18 and 65 years * ASA physical status 1-2 * elective surgery in general anesthesia of 1 to 2 hours * written informed consent
Exclusion criteria
* pregnancy * history of cardiac arrhythmia * presence of any neuromuscular or neurological disease * use of CNS-active medication or abuse of alcohol or illicit drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SSI, compared to standard monitoring variables | during anesthesia |
Countries
Germany
Outcome results
None listed