Early Diabetes Resolution After Weight Loss Surgery

Hormonal and Inflammatory Parameters Affecting Early Diabetes Resolution Following Weight Loss Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00790309

Enrollment

Registered

2008-11-13

Start date

2008-12-31

Completion date

2017-02-28

Last updated

2017-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes, Obesity

Keywords

Obesity, Diabetes, Bariatric surgery

Brief summary

The primary objective is to compare inflammatory, hormonal, and metabolic changes in the very short term after various bariatric surgical procedures (Roux-en Y Gastric Bypass, Vertical Sleeve Gastrectomy, and Adjustable Gastric Banding)and other abdominal surgeries, as well as to compare these changes to diet-induced changes in the same population.

Interventions

PROCEDUREWeight loss surgery

Weight loss surgery

PROCEDURELaparoscopic abdominal surgeries

laparoscopic abdominal surgeries

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

for surgery groups: * BMI of 30 kg/m2 or higher * Ages 18-65 * History of impaired glucose tolerance or T2DM Inclusion Criteria for normal weight group: * BMI of 30 kg/m2 or lower * Ages 18-65

Exclusion criteria

* Development of an intercurrent infection * Prior gastric, duodenal, proximal jejunal surgery or pancreas resection * Current use of thiazolidinediones * Current use of dipeptidyl peptidase-IV inhibitors (e.g., sitagliptin) or glucagon-like peptide-1 analogs (e.g., exenatide) * Any condition felt by the PI or co-investigators to interfere with ability to complete the study

Design outcomes

Primary

Measure	Time frame
Determine to what extent improvements in glycemic control can be attributed to caloric restriction after weight loss surgery	10 days post-op

Secondary

Measure	Time frame
Determine changes in inflammatory markers after weight loss surgery	10 days post-op

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026