Effects of Humidity (During CPAP Treatment) on Mucociliary Clearance in Patients With Obstructive Sleep Apnea

Effects of nCPAP With and Without Humidification on: Inspiratory Temperature, Humidity, Saccharine Transit Time, Nasal Lavage and in Vitro Mucus Properties in Patients With Obstructive Sleep Apnea

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00790166

Acronym

CIA-6

Enrollment

Registered

2008-11-13

Start date

2008-10-31

Completion date

2009-06-24

Last updated

2018-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea

Brief summary

That the level of humidification delivered to patients during CPAP treatment will alter the subjects mucociliary clearance rate and related mucus properties.

Interventions

DEVICECPAP + ThermoSmart™ humidity

an absolute humidity (AH) of 28 mg/l +/- 2mg/l

DEVICECPAP + Conventional humidity

an absolute humidity (AH) of 18 mg/l +/- 2 mg/l

DEVICECPAP + No added humidity

ambient humidity

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Moderate to severe obstructive sleep apnea - Apnea Hypopnea Index (AHI) \> 15 * 75% of events during the diagnostic study must be obstructive

Exclusion criteria

* Currently using CPAP treatment OR have used it in the past 4 weeks * Intolerance of CPAP and/or CPAP mask in the past or during the titration night * Mouth breather (unable to breath through mouth for the study period) * \< 18years old * Nasal CPAP intolerance determined in the PSG-CPAP titration study * Serious nasal issues * Acute upper airway disease * Smoker * COPD * Congestive heart failure * Neuromuscular disease * Stroke

Design outcomes

Primary

Measure	Time frame
mucociliary clearance.	pre and post cpap treatment with varying levels of humidity

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026