Corneal Ulcer
Conditions
Keywords
corneal ulcer, painless, subconjunctival injection, antibiotics, antifungal, lidocaine
Brief summary
The propose of this study is to determine the efficacy of 2% xylocaine in reducing pain due to subconjunctival antibiotic and antifungal injection.
Interventions
PROCEDURELidocaine/NSS
First injection: subconjunctival 2% lidocaine without adrenaline 0.4 ml. before antibiotic injection Second injection (24 hours later): subconjunctival NSS 0.4 ml. before antibiotic injection
PROCEDURENSS/Lidocaine
First injection: subconjunctival NSS 0.4 ml. before antibiotic injection Second injection (24 hours later): subconjunctival 2% lidocaine without adrenaline 0.4 ml. before antibiotic injection
Sponsors
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* The corneal ulcer patients who are diagnosed by ophthalmologist and have 2 of 3 in these following features. 1. corneal epithelial defect with stromal infiltration 2. reaction in anterior chamber 3. positive for bacteria or fungus * The patients have to receive subconjunctival antibiotic injection twice at least. * The patients must be informed consent.
Exclusion criteria
* The patients who have history of allergy of local anesthetics, antibiotics or antifungal drugs. * The patients who administered NSAIDs or weak opioids within 24 hours prior to subconjunctival antibiotic/antifungal injection. * Unable to cooperate with the treatment. * Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numeric rating scale | immediately after injection |
Secondary
| Measure | Time frame |
|---|---|
| Side effects | 24 hours after injection |
Outcome results
None listed