Ischaemic Heart Diseases
Conditions
Keywords
Ischaemia reperfusion, t-PA, Fibrinolysis, Endothelial function
Brief summary
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimise damage to the heart muscle. However in restoring the supply of blood local damage known as ischaemia-reperfusion injury may occur. The aim of this study is to assess how clot forming and clot dissolving pathways are affected during this process, and examine the role of a natural inflammatory hormone, bradykinin. This will help us to understand the mechanism by which ischaemia-reperfusion injury may occur and to devise new treatments for heart attacks.
Interventions
PROCEDUREForearm vascular study
Forearm blood flow measured by venous occlusion plethysmography during interarterial infusion of substance P (2,4,8 pmol/min). Venous blood sampling via cannula in antecubital fossa.
Sponsors
University of Aarhus
University of Oxford
University of Edinburgh
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy males between 18-65 years of ages, non-smokers.
Exclusion criteria
* Any concurrent illness or chronic medical condition. Concurrent use of vasoactive medication. Smoking history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Net t-PA release from the endothelium after ischaemia reperfusion | Throughout the study |
Secondary
| Measure | Time frame |
|---|---|
| Change in forearm blood flow after ischaemia reperfusion | throughout the study |
| Change in platelet-monocyte-binding after ischaemia reperfusion | Throughout the study |
Countries
United Kingdom
Outcome results
None listed