Myocilin Variations and Familial Glaucoma in Taxiarchis

Myocilin Variations and Familial Glaucoma in Taxiarchis, A Small Greek Village.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00788762

Acronym

Taxiarchis

Enrollment

840

Registered

2008-11-11

Start date

2007-08-31

Completion date

2022-12-31

Last updated

2020-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma

Keywords

glaucoma, myocilin

Brief summary

Taxiarchis, a small village in Northern Greece with 1060 inhabitants, was considered to have a surprisingly high incidence of glaucoma. This isolated population located on Mount Holomondas appeared to be enriched for familial glaucoma. Based upon the high reported incidence of glaucoma in Taxiarchis and previous findings of the Thr377Met myocilin mutation in the Greek population,the investigators undertook a community-based study to determine if this variant was present in this village.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Individuals born in Taxiarchis

Exclusion criteria

* Individuals that have not been born in Taxiarchis

Design outcomes

Primary

Measure	Time frame
Examining all of the villagers to determine the actual incidence of glaucoma in Taxiarchis and identify the Thr377Met myocilin mutation in glaucoma patients.	4 years

Countries

Greece

Outcome results