Hysterectomy
Conditions
Keywords
hysterectomy, antibiotic prophylaxis, bacterial vaginosis, tinidazole, cefazolin
Brief summary
Purpose: to compare the efficacy of tinidazole and cefazolin on the prophylaxis of the febrile and infectious morbidity after vaginal or abdominal hysterectomy. Methods: A randomized clinical trial carried out at the Women's Integrated Healthcare Center (CAISM)/UNICAMP, Campinas, Brazil. Women undergoing to total vaginal or abdominal hysterectomy were randomly enrolled into one of these three groups of antibiotic prophylaxis: tinidazole, cefazolin or an association of both.
Detailed description
A randomized clinical trial carried out at the Women's Integrated Healthcare Center (CAISM)/UNICAMP, Campinas, Brazil, to compare the efficacy of tinidazole and cefazolin on the prophylaxis of the febrile and infectious morbidity after vaginal or abdominal hysterectomy. Women undergoing to total vaginal or abdominal hysterectomy were randomly enrolled into one of these three groups of antibiotic prophylaxis: tinidazole, cefazolin or an association of both.
Interventions
DRUGcefazolin
2.0 g, IV, 2 hours before surgery
DRUGtinidazole
2.0 g orally, 12 hours before surgery
DRUGcefazolin plus tinidazole
cefazolin, 2.0 g IV 2 hours before surgery plus tinidazole 2.0 g orally 12 hours before surgery
Sponsors
University of Campinas, Brazil
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
32 Years to 72 Years
Healthy volunteers
No
Inclusion criteria
* women undergoing to hysterectomy due to non-oncologic causes
Exclusion criteria
* previous pelvic infection * antibiotic use within 7 days before surgery * study drugs allergy * immuno-incompetence * urinary tract infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-operative infection | one month after surgery |
Countries
Brazil
Outcome results
None listed