Metabolic Syndrome, Type 2 Diabetes Mellitus
Conditions
Keywords
Mitochondria and Metabolic Syndrome
Brief summary
There has been increasing support for our hypothesis that mitochondrial dysfunction plays an important role in the etiology of Type 2 Diabetes Mellitus and the overlapping Metabolic Syndrome.
Detailed description
Once the mitochondrial defect(s) of these subjects has been defined, the data will be used to develop two non-invasive screening tools to detect mitochondrial defects in Diabetes Mellitus and Metabolic Syndrome patients. The device call Diffuse Optical Spectroscopy develope at Beckman Laser Instituteis is non-invasive measurement technique, to measure the properties of the muscle tisuue and vascular activity (calf, bicep, or the brain)to evaluate the patient's metabolic status and and to assess muscle mitochondrial OXPHOS function.
Interventions
muscle properties scanning
Sponsors
Beckman Laser Institute University of California Irvine
University of California, Irvine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Chinese descent and have been clinically diagnosed with diabetes mellitus (DM) or have met the study criteria for metabolic syndrome (MS).
Exclusion criteria
* non chiness descent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Near Infrared Spectroscopy to assess muscle mitochondrial OXPHOS function. | 4 weeks |
Countries
United States
Outcome results
None listed