Critically Ill
Conditions
Keywords
Mechanical ventilation, Ventilator induced diaphragmatic dysfunction, Weaning, Neuromuscular diseases- Respiratory function tests, Intubated patients in intensive care unit
Brief summary
Animal studies showed that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capacity, called ventilator-induced diaphragmatic dysfunction (VIDD).
Interventions
None listed
Sponsors
University Hospital, Montpellier
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Invasive mechanical ventilation (tracheally intubated or tracheotomized) less than 48h.· * Duration of mechanical ventilation for at least 72h.· * Subject itself or its next of kin has given written informed consent
Exclusion criteria
* Patient is less than 18 years or more than 85 years of age· * The attending physician refuses to allow enrollment· * The patient refuses informed consent * Next of kin is unavailable or refuses informed consent· * Pregnant or breast-feeding female. * A pregnancy test will be performed in all female patients less than 60 years of age.· * Any contraindication to use cervical magnetic stimulation (mechanical cardiac assist device …).· * Presence or suspicion of prior diaphragm injury or chronic disease· * Presence or suspicion of a central nervous system (CNS) disorder, including (but not limited to): CNS infarction, bleeding, tumor, or infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory function parameters | 6 weeks |
Countries
France
Outcome results
None listed