Acute Lung Injury
Conditions
Brief summary
Variable pressure support during assisted spontaneous breathing (noisy PSV) has been shown to improve the respiratory function in experimental acute lung injury (ALI). We aimed at comparing the effects of noisy PSV with traditional PSV on the respiratory function of patients suffering from ALI.
Interventions
OTHERAssisted mechanical ventilation
Patients will be mechanically ventilated with noisy PSV and PSV in random sequence
Sponsors
Technische Universität Dresden
Study design
Primary purpose
TREATMENT
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* age 18 to 75 yrs * 150 mmHg \< PaO2/FIO2 \< 300 mmHg * mechanical ventilation with PSV or BIPAP * less than 15 days of mechanical ventilation * at least 20% of minute ventilation originated from spontaneous breathing
Exclusion criteria
* BMI \> 35 * esophageal disease * neuromuscular disease * instable thorax * pneumothorax * head trauma * brain injury * increased intracranial pressure * agitation * increased need for vasoactive drugs * chronic lung disease * acute coronary disease * participation in another clinical trial within the last 4 weeks at enrollment Interruption criteria: * acute change of mental status * SaO2 \< 92% * pHa \< 7.30 * respiratory rate \> 30 or \< 6 /min * dyspnea * diaphragm/thorax antagonism * diaphoresis * abnormal use of respiratory muscles * increase of the heart rate above 120% of baseline or absolute value \< 60 or \> 130 /min * mean arterial pressure above 120% of baseline or absolute value \< 70 or \> 110 mmHg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect on the arterial oxygenation | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect on the work of breathing | — |
| Effect on PaCO2 | — |
Countries
Germany
Outcome results
None listed