Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI)

Imaging Cardiac Electrical Remodeling With ECGI

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00785564

Enrollment

Registered

2008-11-05

Start date

2007-11-30

Completion date

2011-09-30

Last updated

2019-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sick Sinus Syndrome

Keywords

T-wave memory, Sick Sinus Syndrome

Brief summary

A consequence of chronic RV pacing is a process of electrical remodeling that alters myocardial repolarization to reflect the altered depolarization induced by the RV lead. When RV pacing is discontinued, the altered repolarization persists for several weeks. This phenomena is traditionally described as T-wave memory based upon the 12-lead ECG appearance of inverted T-Waves. The investigators are using the ECGI technique to produce three dimensional electroanatomical images of this phenomena in patients with dual chamber pacemakers. Echocardiography will also be used to image the mechanical effects of RV pacing and T-wave memory. The images will show the spatial distribution of altered repolarization and allow us to correlate any mechanical consequences of this phenomena that may exist.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Implanted dual chamber pacemaker for sick sinus syndrome with no history of complete heart block.

Exclusion criteria

* Persistent atrial fibrillation that is not suppressed by medications.

Design outcomes

Primary

Measure	Time frame
ECGI Image	1 month after RV pacing

Countries

United States

Outcome results