Erythema
Conditions
Keywords
UVB induced skin erythema
Brief summary
Purpose of study: Evaluation of the affect of dose rate on UVR induced skin erythema. Study design: A single-center, prospective, randomized, crossover, open study. Number of patients: 20-40 Patient population: Healthy volunteers Control: Different sites on patients body Procedure duration: Total 3-5 hours (4 visits) Duration of follow up: 4 days Duration of study: Up to 6 months Primary objectives: To examine the difference in erythemal response as a function of dose rate, and to assess the total amount of energy that is theoretically transmitted through a sunscreen within the range of SPF 2-10.
Interventions
DEVICEexposure to UVB radiation
exposure to UVB radiation for limited time in order to establish subject's minimal erythema dose.
Sponsors
Goldenhersh, Michael, M.D.
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Fitzpatrick Skin types I-III. * Age 18-60. * Absence of obvious sun damage on the volar side of the forearm or other exposure sites. * Absence of exposure of the arms or other exposure sites to sunlight for two weeks prior to the experiment.
Exclusion criteria
* History of skin cancer. * Multiple nevi or atypical nevi on the forearm. * Signs of sun damage on the volar side of the forearm or other exposure sites. * Mentally incompetent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To examine the difference in erythemal response as a function of dose rate, and to assess the total amount of energy that is theoretically transmitted through a sunscreen within the range of SPF 2-10 | end of study |
Outcome results
None listed